Many Roots, One Tree–– We strive to create an environment where everyone feels valued, respected, and empowered. We believe that diversity in perspectives, backgrounds, and experience enriches our culture, fuels innovation, and strengthens our commitment to creating new medicines for patients.

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We are always looking for top talent who have passion for creating novel and effective medicines for cancer treatment. 

Our team of experts works tirelessly to discover new and innovative therapies that target a variety of diseases. We use state-of-the-art DNA nanotechnology and cutting-edge research techniques to develop therapeutics that have the potential to change patients' lives.

Postdoctoral Research Scientist 

• Location: On-site at LabCentral, 700 Main Street, Cambridge, MA 02139 
• Employment Type: Full-time 
• Reports To: Lead Scientist and Company Leadership 
• Compensation: Salary equivalent to the NIH postdoctoral pay scale, plus startup equity, with an opportunity for rapid promotion to a Scientist role and a corresponding salary adjustment upon successful completion of training. 
• About DoriNano 
• DoriNano is a biotechnology startup developing programmable DNA origami nanoparticles for therapeutic delivery. Spun out of Dana-Farber, Harvard, and the Wyss Institute, we are advancing next-generation drug delivery technologies. 
• About the Role 
• We are seeking a motivated Postdoctoral Research Scientist to advance our DNA origami nanoparticle platform for therapeutic delivery. This hands-on research role will focus on developing and optimizing nanoparticle production and characterization, while investigating biological cargo delivery in cellular and preclinical models. 
• This position combines independent, hypothesis-driven research with mentorship and scientific development. You will shape research questions, design and interpret experiments, and help disseminate findings through manuscripts and scientific presentations, while collaborating with a multidisciplinary team. 
• Duties and Responsibilities 
• Design, optimize, and execute DNA origami nanoparticle assembly, purification, and characterization workflows; establish reproducibility and quality-control criteria. 
• Develop and evaluate nanoparticle formulations and conjugation strategies, including preparation of DNA origami constructs for siRNA delivery. 
• Independently troubleshoot experimental challenges, analyze results, and propose data-driven improvements to platform performance. 
• Plan and conduct biological cargo delivery studies, including cellular uptake, marker expression, and cell viability assays. 
• Perform mammalian cell culture and molecular biology assays, including nucleic acid purification, gel electrophoresis, PCR, and RT-qPCR. 
• Design and support in vivo mouse studies, including dosing, sample collection, and downstream tissue analyses, in accordance with approved animal protocols and training. 
• Develop research findings into scientific manuscripts and conference abstracts; present results at internal seminars and external scientific meetings, subject to IP and publication review. 
• Collaborate across research functions and participate in scientific discussions and literature reviews. 
• Required Qualifications 
• PhD in Molecular Biology, Bioengineering, Biochemistry, Nanotechnology, Biomedical Sciences, Immunology, or a closely related discipline with 0+ years of post-PhD experience. 
• Strong practical experience in molecular biology, nucleic acid methods, or nanoparticle-related experimental research. 
• Experience with mammalian cell culture and quantitative analysis of cell-based experiments. 
• Excellent scientific communication, organization, data analysis, and collaborative problem-solving skills. 
• Peer-reviewed publications, particularly first-author work, conference presentations, or experience preparing manuscripts. 
• Preferred Qualifications 
• Research experience in DNA nanotechnology, DNA origami, nucleic acid therapeutics, nanomedicine, or drug delivery. 
• Experience with siRNA/RNAi/mRNA, RT-qPCR, fluorescence microscopy, flow cytometry, or cell-based delivery assays. 
• Prior mouse handling, dosing, tissue collection, or in vivo therapeutic delivery experience. 
• Familiarity with nanoparticle characterization and data-analysis tools. 
• What We Offer 
• Opportunity to pursue hypothesis-driven research at the interface of DNA nanotechnology and therapeutic delivery, with the potential to publish peer-reviewed findings. 
• Scientific mentorship, opportunities to develop independent research directions, and support for manuscript preparation, conference participation, and career development. 
• A collaborative startup environment with opportunities to translate research into platform advances. 
• Competitive compensation and equity opportunities. 
• Access to scientific seminars and networking opportunities in the Cambridge biotech ecosystem. 
• To Apply 
• Please submit a CV (including publications), a brief cover letter outlining your doctoral research, scientific interests, and relevant expertise, and contact information for three professional references to info@dorinano.com. Use the subject line: “Postdoctoral Research Scientist Application – FirstName LastName”. 
• Equal Opportunity Employer 
• DoriNano is an equal opportunity employer and considers qualified applicants in accordance with applicable federal, state, and local employment laws. 
• Work Authorization 
• Candidates must be currently authorized to work in the United States. DoriNano is unable to provide visa sponsorship at this time.